关键建立新毒理学研究偏离修改传统方法
新兴意义设计高性纳米材料继续研究未更程度利广泛生物医学越越关注出现寻常意想毒性需性更高反应寻常复杂形状障碍细胞造材料具纳米级[114]建立新毒理学研究偏离修改常规方法必少
纳米粒子影响难评估生物学素细胞吸收体行排泄种素控制改变组成形态路线剂量显着影响免疫反应毒副作外预见细胞毒性毒性试验干扰控制足属性影响特定结果
方面纳米特殊焦点问题提供机会阅读讨显著纳米毒理学研究工作方面新方法生物模型实验关注Drezek事目前已提供广泛审查纳米生物分布毒性状态研究[15]作者讨长期体研究必性充分调查毒性免疫反应排泄纳米粒子需时间体外实验中走系统化方法纳米粒子间改进相关属性观察影响解决新兴纳米技术安全标准库克事审查讨
目前体外毒性分析检测性重问题性组建议系列控件
提高实验质量增加纳米技术安全持续利未[16]外李事强调重纳米粒子细胞毒性实验影响素改进实验注意事项需解决问题获数更界定利影响纳米粒子[17]波特事审查讨表征碳纳米毒性互补纳米测量需理化性质毒性[18]作者建议组合高分辨率电子显微镜解技术细胞活力检测网站定位毒性机制稳定细胞碳纳米组织关纳米材料具体类Fubini定讨类纳米粒子高宽重点相关特性导致毒性作[19]作者指出形式组合相似处足建立毒性规模效应形式耐久性组成表面改性必须追究高长宽纳米粒子蔡财提供概述细胞摄取机制行层状双金属氢氧化物毒性体外体注重效果理化性质剂量互动生物相容性生物系统
[20]张BAUMER研究文章中蒙泰罗里维耶尔探讨毒性细胞树突状细胞量子点吸收脱落细胞赖新光源摄取细胞类型细胞分化途径[21]加西亚·贝特出概述序介孔纳米材料应集中高表面积孔体积装载释放力等纳米粒子行[22]stensberg事提供激烈讨
研究运输活动细胞纳米银生命生物体水传统方式结合成立纳米粒子方法表征[23]作者提出基样研究机制调查新银纳米粒子吸收运动建立更模型评估长期体影响研究集中改善生物相容性新型纳米粒子毒性限制提出问题陈周讨战略疏水纳米粒子双亲聚合物限度减少毒性增强纳米粒子稳定性聚合物保护壳[24]李某事谈成功评价生物相容性聚巴胺专注血液中免疫原性组织炎症反应[25]该组发现聚巴胺提供生物相容性纳米涂层材料表面会否表现出定程度毒性 leeand事提供透视纳米粒子作解毒方法物种通身体讨作台二氧化硅纳米化学氧化活性降低毒化合物[做研究[26]
鉴越越关注两新纳米功材料发展健康环境问题关系材料领域研究员负责完整理解纳米材料理化性质开发新标准建立新标准领域识需长时间(10年)然寻求新纳米医学技术会造成延迟
参考书目
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