15. 双膦酸药物的研发进展1970 1980 1990 2000含氮环形侧链具有更强的抗骨吸收效果,效果强于依替膦酸约10,000倍R. GRAHAM G. RUSSELL, Bisphosphonates, From Bench to Beside Ann. N.Y. Acad. Sci. 1068: 367–401 (2006).
R. GRAHAM G. RUSSELL, Bisphosphonates,An Update on Mechanisms of Action and How These Relate to Clinical Efficacy
R. GRAHAM G. RUSSELL, Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int (2008) 19:733–759长期使用会影响骨矿化
骨折危险性
22. 高吸附力的双膦酸药物在骨组织中很少弥散,停留在骨组织表面BPBPBPBP被破骨细胞吸收的药物通过循环后再吸附作用BP局部低脱离BP迅速吸收R.G.G. Russell / Bone 40 (2007) S21–S25
注射后几个月内组织液中仍可检测到双膦酸类药物独特双氮结构使唑来膦酸与骨矿盐具有强大结合力, 从而具有更长作用周期:药物在骨组织的循环使密固达具有长久疗效