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Pasteur
Louis Pasteur was born on December 27 1822 in Dole in the region of Jura France His discovery that most infectious diseases are caused by germs known as the germ theory of disease is one of the most important in medical history His work became the foundation for the science of microbiology and a cornerstone of modern medicine
Pasteur's phenomenal contributions to microbiology and medicine can be summarized as follows First he championed changes in hospital practices to minimize the spread of disease by microbes Second he discovered that weakened forms of a microbe could be used as an immunization against more virulent forms of the microbe Third Pasteur found that rabies was transmitted by agents so small they could not be seen under a microscope thus revealing the world of viruses As a result he developed techniques to vaccinate dogs against rabies and to treat humans bitten by rabid dogs And fourth Pasteur developed pasteurization a process by which harmful microbes in perishable food products are destroyed using heat without destroying the food
His Works
Each discovery in the body of Pasteur's work represents a link in an uninterrupted chain beginning with molecular asymmetry and ending with his rabies prophylaxis by way of his research in fermentation silkworm wine and beer diseases asepsis and vaccines
From Crystallography to Molecular Asymmetry
In 1847 at the age of 26 Pasteur did his first work on molecular asymmetry bringing together the principles of crystallography chemistry and optics He formulated a fundamental law asymmetry differentiates the organic world from the mineral world In other words asymmetric molecules are always the product of life forces His work became the basis of a new science stereochemistry
Research on Fermentation and Spontaneous Generation
At the request of a distiller named Bigo from the north of France Pasteur began to examine why alcohol becomes contaminated with undesirable substances during fermentation He soon demonstrated that each sort of fermentation is linked to the existence of a specific microorganism or ferment a living being that one can study by cultivation in an appropriate sterile medium This insight is the basis of microbiology
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Pasteur delivered the fatal blow to the doctrine of spontaneous generation the theory held for 20 centuries that life could arise spontaneously in organic materials He also developed a germ theory At the same time he discovered the existence of life without oxygen
Fermentation is the consequence of life without air The discovery of anaerobic life paved the way for the study of germs that cause septicemia and gangrene among other infections Thanks to Pasteur it became possible to devise techniques to kill microbes and to control contamination
Technique of Pasteurization
Emperor Napoleon III asked Pasteur to investigate the diseases afflicting wine which were causing considerable economic losses to the wine industry Pasteur went to a vineyard in Arbois in 1864 to study this problem He demonstrated that wine diseases are caused by microorganisms that can be killed by heating the wine to 55degC for several minutes Applied to beer and milk this process called pasteurization soon came into use throughout the world
Research on Infectious Diseases Afflicting Man and Animal
In 1865 Pasteur began to study the silkworm diseases that were crippling the silk industry in France He discovered the infectious agents and revealed the manner in which these agents are transmittedby contagion and hereditary principle and how to prevent them Elaborating on his study of fermentation he could now confirm that each disease is caused by a specific microbe and that these microbes are foreign elements With this knowledge Pasteur was able to establish the basic rules of sterilization or asepsis Preventing contagion and infection his method of sterilization revolutionized surgery and obstetrics
From 1877 to 1887 Pasteur employed these fundamentals of microbiology in the battle against infectious diseases He went on to discover three bacteria responsible for human illnesses staphylococcus streptococcus and pneumococcus
Treatment and Prevention of Rabies
Louis Pasteur discovered the method for the attenuation of virulent microorganisms that is the basis of vaccination He developed vaccines against chicken cholera anthrax and swine erysipelas After mastering his method of vaccination he applied this concept to rabies On July 6 1885 Pasteur tested his pioneering rabies treatment on man for the first time the young Joseph Meister was saved
The Creation of the Pasteur Institute
On March 1 1886 Pasteur presented the results of his rabies treatment to the Academy of
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Sciences and called for the creation of a rabies vaccine center An extensive international public drive for funds financed the construction of the Pasteur Institute a private stateapproved institute recognized by the President of France Jules Grévy in 1887 and inaugurated by his successor Sadi Carnot in 1888 In accordance with Pasteur's wishes the Institute was founded as a clinic for rabies treatment a research center for infectious disease and a teaching center
The 66yearold scientist went on to dedicate the last seven years of his life to the Institute that still bears his name During this period Pasteur also came to know the joys of fame and was honored throughout the world with prestigious decorations
His work was continued and amplified throughout the world by his disciples the Pasteuriens
A Man of Freedom and Rigor
Pasteur's work is not simply the sum of his discoveries It also represents the revolution of scientific methodology Pasteur superimposed two indisputable rules of modern research the freedom of creative imagination necessarily subjected to rigorous experimentation He would teach his disciples
Do not put forward anything that you cannot prove by experimentation
Louis Pasteur was a humanist always working towards the improvement of the human condition He was a free man who never hesitated to take issue with the prevailing yet false ideas of his time
He ascribed particular importance to the spread of knowledge and the applications of research
In the scientist's lifetime Pasteurien theory and method were put into use well beyond the borders of France
Fully aware of the international importance of his work Pasteur's disciples dispersed themselves wherever their assistance was needed In 1891 the first Foreign Institut Pasteur was founded in Saigon (today Ho Chi Minh City Vietnam) launching what was to become a vast international network of Instituts Pasteur
Because he changed the world forever his homeland and the world have long considered him a benefactor of humanity
路易斯·巴斯德(公元18221895年)法国微生物学家化学家研究微生物类型性营养繁殖作等奠定工业微生物学医学微生物学基础开创微生物生理学循前进战胜狂犬病鸡霍乱炭疽病蚕病等方面取成果英国
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